buku sofyan dahlan metodologi penelitian

Subjects were divided into 2 groups, the exposure group (group given treatment) and control group. The design of this study was clinical trial pre and post design, randomized, double blind and placebo controlled, on 34 new recruit soldiers in Artillery Academy of Indonesian Army, during the soldiers were trained to firing Howitzer 105 artillery weapon, from 7 th-10 th July 2014 in Cimahi and Batujajar. Â Â Â Â Aim of this study was to determine the impact of glutathione peroxidase mimetic to glutathione peroxidase and malondialdehyde level in blood, also otoacoustic emission value on soldiers with risk of TA due to explosion of Howitzer 105 artillery weapon. Cellular mechanism of glutation peroxidase mimetic was similar as GPx. Defense mechanism toward oxidative stress was mediated by endogenous antioxidant enyzme (superoxide dismutase/SOD, catalase/CAT, and GPx).

Oxidative stress was characterized by increasing of malondialdehyde (MDA), decreasing of glutathione peroxidase (GPx) enzyme, and abnormal otoacoustic emission value (refer). Oxidative stress which caused by increasing of free radical ROS/RNS in the organs of Corti, causing apoptosis and necrosis of cochlear hair cell. Medical Faculty of General Achmad Yani UniversityĪcoustic trauma, Ebselen, GPx, MDA, Otoacoustic emission, AbstractĮxcessive noise exposure may cause mechanical and metabolic (oxidative stress) to the inner ear structure (cochlea), resulting in acoustic trauma (TA).

Buku sofyan dahlan metodologi penelitian